BioPerine and How It Works

Last month we looked at AstraGin®, so I thought why not cover another absorption enhancer, BioPerine®. BioPerine® is a patented source of black pepper extract from the Sabinsa Corporation that is standardised for at least 95% piperine. Piperine is the polysaccharide that is responsible for black pepper's pungency and it enhances the absorption of ingredients a few ways.

Let's look at Sabinsa's claims:

A natural bioavailability enhancer for nutrients

  • Herbal extracts
    • e.g. curcumin, Boswellin®, ashwagandha, Gingko biloba, capsaicin
  • Water-soluble vitamins
    • e.g. vitamin B1, vitamin B2, niacinamide, vitamin B6, vitamin B12, folic acid, vitamin C
  • Fat-soluble vitamins
    • e.g. vitamin A, vitamin D, vitamin E, vitamin K
  • Antioxidants
    • e.g. vitamin A, vitamin C, vitamin E, alpha-carotene, transbeta-carotene, beta-cryptoxanthin, lycopene, lutein/zeaxanthin, pine bark bioflavanoids complex, germanium, selenium, zinc
  • Amino Acids
    • e.g. lysine, isoleucine, leucine, threonoine, valine, tryptophan, phenylalanine, methionine
  • Minerals
    • e.g calcium, iron, zinc, vanadium, selenium, chromium, iodine, potassium, manganese, copper, magnesium

Possible mechanisms for increased nutrient bioavailability using BioPerine®

  • Non specific mechanisms promoting rapid absorption of nutrients
    • Increases blood supply to the GI tract
  • Water-soluble vitamins
    • Increases emulsifying content of the gut
  • Fat-soluble vitamins
    • Increases active nutrient transport

That's a pretty thorough list of benefits! So how does BioPerine® work?

With glucuronides (sugars), BioPerine® inhibits small intestinal glucuronidation. Glucuronidated compounds have a glycosidic bond, a link that joins a carbohydrate molecule to another molecule. This mode of action is caused by inhibition of uridine 5'-diphospho-glucuronosyltransferase (UGT), the glycosyltransferase enzymes that catalyze glucuronidation of compounds. In other words BioPerine® stops the breakdown of glucuronides.

The most known way BioPerine® works is by inhibing cytochrome P450 3A4 (CYP3A4). Cytochrome P450 enzymes located in the liver and small intestines are essential for the metabolism of over 50% of medicines and endogenous compounds. CYP3A4 contributes to bile acid detoxification, terminates the active of steroid hormones, and elimination of phytochemicals and drugs. By inhibiting CYP3A4 you can significantly increase the bioavailability of CYP3A4 substrates. This is why it is not recommended to take anything with BioPerine® in at the same time as any medication. This is why many people and brands have switched over to AstraGin.

BioPerine® also inhibits permeability glycoprotein (P-gp) (Bhardwaj et al. 2002). P-gp is a plasma membrane protein which acts as a drug transport mechanism, a kind of transmembrane pump which removes drugs from the cell membrane and cytoplasm. By blocking P-gp you increase the absorption of ingredients.

There is evidence of BioPerine® displaying neurocognitive benefits due to its activity on the cholinergic system by inhibiting acetylcholinesterase, which in turn enhances choline sources.

BioPerine® has also shown to be a monoamine oxidase B (MAO-B) inhibitor. MAO-B levels naturally increase with age and contribute to cellular degeneration by producing hydrogen peroxides, that are converted by iron to highly toxic oxygen free radicals. This leads to cell death.

Dopamine is mainly metabolised by MAO-B and thus by inhibiting MAO-B you allow greater levels of dopamine in the brain, as well as an increase in dopamine levels produced from levodopa and is inherently neuroprotective. MAO-B inhibition also protects the breakdown of circulating phenylethylamine, which is biosynthesized from the amino acid phenylalanine.

It is easy to see why so many products use BioPerine® and the fact it has been around for over 20 years, it has lasted the test of time, proven itself the world over and is a fine addition to your supplement regime. The clinical dosage is 5-10mg per use.

So out of BioPerine® vs AstraGin, which do you use? As long as you get 95% piperine, you get the same benefits as BioPerine®, so buy yourself a bottle of STROM MAXimise and get the best of both worlds.

  • Jun 15, 2020
  • Category: Blog
  • Comments: 0
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