Good morning fellow lockdowners, or whatever time of the day you are reading this. I've lost track of the days now haha.
Anyway, I am currently sat at my desk looking at a tub of Complete Strength Pre V2 in my hand, having just finished a home workout and being a sweaty mess, and I am reading the label which is pretty impressive. Then my eyes catch AstraGin® and I realised I don't think I've ever written about this ingredient. Not properly anyway. So of we go!
First, lets start with with pretty explanatory sentence straight from the guys who make this stuff, NuLiv Science
"AstraGin® is a patented, 100% natural compound that increases absorption of many vital nutrients promoting a healthy gut environment"
- Increases the steady-state absorption rate of arginine, agmatine, β-alanine, citrulline, creatine, leucine, peptides and tryptophan by 67%, 36%, 25%,45%, 33%, 58%, 41% and 53% (1)
- Increase curcumin absorption by 92% (2)
- Increases vitamins absorption such as folate by 50% (3)
- Increases polyunsaturated fatty acid (derived from flax oil and fish oil) by 58% and 100% (4)
- Increase glucosamine absorption by 23% (5)
- Increases omega-7 fatty acid (Palmitoleic acid) by 39% (6)
- Increase ATP production in liver by 18% (7)
- Reduce intestinal wall inflammation by 73% (8)
There we go, now you know. Thank you for reading and have a great day! Wait, you want more? It is a pharmaceutical-grade blend of Panax Notoginseng and Astragalus Membranaceus in a 1:1 ratio. There we go, take care.
Ok, ok, I'll explain more. Most nutrients we consume are absorbed through the small intestine. By stimulating different transporter molecules such as SGLT1 and CAT1, and the messenger mRNA, AstraGin® augments nutrient absorption allowing more to pass through the intestinal wall and travel into the blood stream. Now, lets make learning easier by including some videos. I don't know about you but I learn easier by seeing instead of just reading.
SGLT1 (Sodium-glucose co-transporter 1) is a low-capacity, high-affinity transporter that mediates around 4-6% of glucose re-absorption, as well as being the primary glucose co-transporter in the small intestine.
Ok, but what about fatty acids? How do we transport fats into the small intestine? That is where CAT1 comes iunto play. CAT1 is short for carnitine acyltransferase 1, but also known a Carnitine palmitoyltransferase I (CPT1).
Now you know how AstraGin® increases carbohydrate absorption and fats, what about proteins? This is where mRNA manipulation comes into play. Most the mechanisms known to regulate protein synthesis involve modulating the initiation phase of mRNA (Messenger RNA).
To understand mRNA, check out this video which does an excellent job explaining it.
As we get older, these transporter molecules decline making it harder to absorb the nutrients we require. A poor lifestyle can also effect the transporter rate, which is one reason those you eat a balanced diet and do regular exercise are healthier (other reasons come into play of course such as obesity etc, but let's not get side tracked.)
Another way AstraGin® works is by triggering the mTOR pathway. Exercice activates mammalian target of rapamycin, or mTOR for short. It is considered a key regulator of muscle signalling and protein synthesis, putting you into the anabolic state. mTOR then activates S6K1 to increase protein synthesis required to for skeletal muscle hypertrophy, and general tissue growth. By activating mTOR (as well as mRNA) you increase the absorption of amino acids due to increasing protein synthesis. If you didn't know already, amino acids are proteins.
By synergistically stimulating the absorption of fats, carbs and protein it is easy to see how AstraGin® would make a great addition to any supplement.